1SVC

NFKB P50 HOMODIMER BOUND TO DNA

1SVC の概要

• エントリーDOI: 10.2210/pdb1svc/pdb
• 分子名称: DNA (5'-D(*AP*GP*AP*TP*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*CP*TP*A P*GP*A)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB)) (3 entities in total)
• 機能のキーワード: dna-binding, transcription regulation, activator, nuclear protein, phosphorylation, dna, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P19838
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47007.68

構造登録者

Mueller, C.W.,Harrison, S.C. (登録日: 1995-11-27, 公開日: 1996-06-10, 最終更新日: 2024-02-14)

主引用文献

Muller, C.W.,Rey, F.A.,Sodeoka, M.,Verdine, G.L.,Harrison, S.C.
Structure of the NF-kappa B p50 homodimer bound to DNA.
Nature, 373:311-317, 1995

PubMed Abstract: The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53.

PubMed: 7830764
DOI: 10.1038/373311a0

実験手法

X-RAY DIFFRACTION (2.6 Å)