1SV5
CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335
1SV5 の概要
エントリーDOI | 10.2210/pdb1sv5/pdb |
関連するPDBエントリー | 1DLO 1HNI 1HNV 1S6P 1S6Q 1S9E 1S9G 1SUQ 1TVR 2HMI |
分子名称 | Reverse Transcriptase, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE (3 entities in total) |
機能のキーワード | aids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, drug resistance, transferase |
由来する生物種 | Human immunodeficiency virus 1 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 115187.85 |
構造登録者 | |
主引用文献 | Das, K.,Clark Jr., A.D.,Lewi, P.J.,Heeres, J.,De Jonge, M.R.,Koymans, L.M.,Vinkers, H.M.,Daeyaert, F.,Ludovici, D.W.,Kukla, M.J.,De Corte, B.,Kavash, R.W.,Ho, C.Y.,Ye, H.,Lichtenstein, M.A.,Andries, K.,Pauwles, R.,Debethune, M.-P.,Boyer, P.L.,Clark, P.,Hughes, S.H.,Janssen, P.A.,Arnold, E. Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants J.Med.Chem., 47:2550-2560, 2004 Cited by PubMed: 15115397DOI: 10.1021/jm030558s 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
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