1SUV

Structure of Human Transferrin Receptor-Transferrin Complex

1SUV の概要

• エントリーDOI: 10.2210/pdb1suv/pdb
• 関連するPDBエントリー: 1A8E 1CX8 1JNF
• 分子名称: Transferrin receptor protein 1, Serotransferrin, N-lobe, Serotransferrin, C-lobe, ... (5 entities in total)
• 機能のキーワード: protein complex, metal transport
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Transferrin receptor protein 1, serum form: Secreted: P02786; Secreted: P02787
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 293127.06

構造登録者

Cheng, Y.,Zak, O.,Aisen, P.,Harrison, S.C.,Walz, T. (登録日: 2004-03-26, 公開日: 2004-04-13, 最終更新日: 2024-10-30)

主引用文献

Cheng, Y.,Zak, O.,Aisen, P.,Harrison, S.C.,Walz, T.
Structure of the Human Transferrin Receptor-Transferrin Complex
Cell(Cambridge,Mass.), 116:565-576, 2004

PubMed Abstract: Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cryo-electron microscopy, we have produced a density map of the TfR-Tf complex at subnanometer resolution. An atomic model, obtained by fitting crystal structures of diferric Tf and the receptor ectodomain into the map, shows that the Tf N-lobe is sandwiched between the membrane and the TfR ectodomain and that the C-lobe abuts the receptor helical domain. When Tf binds receptor, its N-lobe moves by about 9 A with respect to its C-lobe. The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf.

PubMed: 14980223
DOI: 10.1016/S0092-8674(04)00130-8

実験手法

ELECTRON MICROSCOPY (7.5 Å)