1SOX

SULFITE OXIDASE FROM CHICKEN LIVER

1SOX の概要

• エントリーDOI: 10.2210/pdb1sox/pdb
• 分子名称: SULFITE OXIDASE, SULFATE ION, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, sulfite oxidation
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Mitochondrion intermembrane space: P07850
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104932.58

構造登録者

Kisker, C.,Schindelin, H.,Rees, D.C. (登録日: 1997-12-31, 公開日: 1998-04-29, 最終更新日: 2024-05-22)

主引用文献

Kisker, C.,Schindelin, H.,Pacheco, A.,Wehbi, W.A.,Garrett, R.M.,Rajagopalan, K.V.,Enemark, J.H.,Rees, D.C.
Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase.
Cell(Cambridge,Mass.), 91:973-983, 1997

PubMed Abstract: The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfite oxidase at 1.9 A resolution reveals that each monomer of the dimeric enzyme consists of three domains. At the active site, the Mo is penta-coordinated by three sulfur ligands, one oxo group, and one water/hydroxo. A sulfate molecule adjacent to the Mo identifies the substrate binding pocket. Four variants associated with sulfite oxidase deficiency have been identified: two mutations are near the sulfate binding site, while the other mutations occur within the domain mediating dimerization.

PubMed: 9428520
DOI: 10.1016/S0092-8674(00)80488-2

実験手法

X-RAY DIFFRACTION (1.9 Å)