1SO8

Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]

Summary for 1SO8

Entry DOI	10.2210/pdb1so8/pdb
Descriptor	3-hydroxyacyl-CoA dehydrogenase type II, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	alcohol dehydrogenase; rossmann fold; abeta-induced distorsion, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion: Q99714
Total number of polymer chains	1
Total formula weight	27028.45
Authors	Lustbader, J.W.,Cirilli, M.,Wu, H. (deposition date: 2004-03-13, release date: 2004-05-11, Last modification date: 2024-02-14)
Primary citation	Lustbader, J.W.,Cirilli, M.,Lin, C.,Xu, H.W.,Takuma, K.,Wang, N.,Caspersen, C.,Chen, X.,Pollak, S.,Chaney, M.,Trinchese, F.,Gunn-Moore, F.,Lue, L.F.,Walker, D.G.,Kuppusamy, P.,Zewier, Z.L.,Arancio, O.,Stern, D.,Yan, S.S.,Wu, H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science, 304:448-452, 2004 Cited by PubMed: 15087549 DOI: 10.1126/science.1091230 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation