1SLC

X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES

1SLC の概要

• エントリーDOI: 10.2210/pdb1slc/pdb
• 分子名称: BOVINE GALECTIN-1, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: complex(lectin-saccharide), complex(lectin-saccharide) complex, complex(lectin/saccharide)
• 由来する生物種: Bos taurus (cow)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 61386.63

構造登録者

Bourne, Y.,Cambillau, C. (登録日: 1994-03-12, 公開日: 1995-01-26, 最終更新日: 2024-10-23)

主引用文献

Bourne, Y.,Bolgiano, B.,Liao, D.I.,Strecker, G.,Cantau, P.,Herzberg, O.,Feizi, T.,Cambillau, C.
Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.
Nat.Struct.Biol., 1:863-870, 1994

PubMed Abstract: Galectins are beta-galactoside-binding proteins that occur intra- and extracellularly in many animal tissues. They have been proposed to form networks of glycoconjugates on the cell surface, where they may modulate various cell response pathways such as growth, activation and adhesion. The high resolution X-ray crystallographic analyses of three crystal forms of bovine galectin-1 in complex with biantennary saccharides of N-acetyllactosamine type reveal infinite chains of lectin dimers cross-linked through N-acetyllactosamine units located at the end of the oligosaccharide antenna. The oligosaccharide adopts a different low energy conformation in each of the three crystal forms.

PubMed: 7773775
DOI: 10.1038/nsb1294-863

実験手法

X-RAY DIFFRACTION (2.15 Å)