1SKJ

COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX

1SKJ の概要

• エントリーDOI: 10.2210/pdb1skj/pdb
• 分子名称: PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID (3 entities in total)
• 機能のキーワード: tyrosine-protein kinase, v-src sh2 domain, phosphotyrosine recognition domain, pp60 src sh2 domain, peptidomimetic, ureido
• 由来する生物種: Rous sarcoma virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13479.07

構造登録者

Holland, D.R.,Rubin, J.R. (登録日: 1997-09-18, 公開日: 1998-02-25, 最終更新日: 2023-08-09)

• 主引用文献: Plummer, M.S.,Holland, D.R.,Shahripour, A.,Lunney, E.A.,Fergus, J.H.,Marks, J.S.,McConnell, P.,Mueller, W.T.,Sawyer, T.K.; Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.; J.Med.Chem., 40:3719-3725, 1997; PubMed: 9371236; DOI: 10.1021/jm970402q

実験手法

X-RAY DIFFRACTION (2 Å)