1SDU
Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
Summary for 1SDU
Entry DOI | 10.2210/pdb1sdu/pdb |
Related | 1FF0 1SDT 1SDV |
Descriptor | protease RETROPEPSIN, SULFATE ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | drug resistance hiv-1 protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22286.33 |
Authors | Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2004-02-14, release date: 2004-05-25, Last modification date: 2024-02-14) |
Primary citation | Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site Eur.J.Biochem., 271:1516-1524, 2004 Cited by PubMed: 15066177DOI: 10.1111/j.1432-1033.2004.04060.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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