1S9E
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385
Summary for 1S9E
Entry DOI | 10.2210/pdb1s9e/pdb |
Related | 1DLO 1HNI 1HNV 1S6P 1S6Q 1S9E 1TVR 2HMI |
Descriptor | POL polyprotein [Contains:Reverse transcriptase], POL polyprotein [Contains: Reverse transcriptase], 4-[4-AMINO-6-(2,6-DICHLORO-PHENOXY)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE, ... (4 entities in total) |
Functional Keywords | reverse transcriptase, rt, nnrti, nonnucleoside inhibitor, protein-inhibitor complex, hiv, aids, drug design, r129385, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 115155.92 |
Authors | Das, K.,Clark Jr., A.D.,Ludovici, D.W.,Kukla, M.J.,Decorte, B.,Lewi, P.J.,Hughes, S.H.,Janssen, P.A.,Arnold, E. (deposition date: 2004-02-04, release date: 2004-05-11, Last modification date: 2024-02-14) |
Primary citation | Das, K.,Clark, A.D.,Lewi, P.J.,Heeres, J.,De Jonge, M.R.,Koymans, L.M.,Vinkers, H.M.,Daeyaert, F.,Ludovici, D.W.,Kukla, M.J.,De Corte, B.,Kavash, R.W.,Ho, C.Y.,Ye, H.,Lichtenstein, M.A.,Andries, K.,Pauwels, R.,Boyer, P.L.,Clark, P.,Hughes, S.H.,Janssen, P.A.,Arnold, E. Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants. J.Med.Chem., 47:2550-2560, 2004 Cited by PubMed: 15115397DOI: 10.1021/jm030558s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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