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1S9E

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385

1S9E の概要
エントリーDOI10.2210/pdb1s9e/pdb
関連するPDBエントリー1DLO 1HNI 1HNV 1S6P 1S6Q 1S9E 1TVR 2HMI
分子名称POL polyprotein [Contains:Reverse transcriptase], POL polyprotein [Contains: Reverse transcriptase], 4-[4-AMINO-6-(2,6-DICHLORO-PHENOXY)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE, ... (4 entities in total)
機能のキーワードreverse transcriptase, rt, nnrti, nonnucleoside inhibitor, protein-inhibitor complex, hiv, aids, drug design, r129385, transferase
由来する生物種Human immunodeficiency virus 1
詳細
細胞内の位置Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
タンパク質・核酸の鎖数2
化学式量合計115155.92
構造登録者
Das, K.,Clark Jr., A.D.,Ludovici, D.W.,Kukla, M.J.,Decorte, B.,Lewi, P.J.,Hughes, S.H.,Janssen, P.A.,Arnold, E. (登録日: 2004-02-04, 公開日: 2004-05-11, 最終更新日: 2024-02-14)
主引用文献Das, K.,Clark, A.D.,Lewi, P.J.,Heeres, J.,De Jonge, M.R.,Koymans, L.M.,Vinkers, H.M.,Daeyaert, F.,Ludovici, D.W.,Kukla, M.J.,De Corte, B.,Kavash, R.W.,Ho, C.Y.,Ye, H.,Lichtenstein, M.A.,Andries, K.,Pauwels, R.,Boyer, P.L.,Clark, P.,Hughes, S.H.,Janssen, P.A.,Arnold, E.
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants.
J.Med.Chem., 47:2550-2560, 2004
Cited by
PubMed: 15115397
DOI: 10.1021/jm030558s
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.6 Å)
構造検証レポート
Validation report summary of 1s9e
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-07-24に公開中

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