1S58

The structure of B19 parvovirus capsid

1S58 の概要

• エントリーDOI: 10.2210/pdb1s58/pdb
• 関連するPDBエントリー: 1dnv 1FPV 1K3V 1LP3 1mvm 4dpv
• 分子名称: B19 parvovirus capsid (1 entity in total)
• 機能のキーワード: icosahedral capsid, beta-barrel, icosahedral virus, virus
• 由来する生物種: Human parvovirus B19
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60930.05

構造登録者

Kaufmann, B.,Simpson, A.A.,Rossmann, M.G. (登録日: 2004-01-20, 公開日: 2004-08-17, 最終更新日: 2024-04-03)

主引用文献

Kaufmann, B.,Simpson, A.A.,Rossmann, M.G.
The structure of human parvovirus B19.
Proc.Natl.Acad.Sci.USA, 101:11628-11633, 2004

PubMed Abstract: Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to that found in many icosahedral viruses. The large loops connecting the strands of the beta-barrel form surface features that differentiate B19 from other parvoviruses. Although B19 VP2 has only 26% sequence identity to VP3 of adeno-associated virus, 72% of the C(alpha) atoms can be aligned structurally with a rms deviation of 1.8 A. Both viruses require an integrin as a coreceptor, and conserved surface features suggest a common receptor-binding region.

PubMed: 15289612
DOI: 10.1073/pnas.0402992101

実験手法

X-RAY DIFFRACTION (3.5 Å)