1S48

Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV

Summary for 1S48

• Entry DOI: 10.2210/pdb1s48/pdb
• Related: 1S49 1S4F
• Descriptor: RNA-dependent RNA polymerase (1 entity in total)
• Functional Keywords: polymerase, primer independent initiation, de novo initiation, rna virus, bvdv, bovine viral diarrhea virus, replication, rna binding protein
• Biological source: Bovine viral diarrhea virus 1
• Cellular location: E(rns) glycoprotein: Host membrane; Peripheral membrane protein. Envelope glycoprotein E2: Host cell surface. Cysteine protease NS2: Host membrane; Multi- pass membrane protein (Potential): P19711
• Total number of polymer chains: 1
• Total formula weight: 70490.74

Authors

Choi, K.H.,Groarke, J.M.,Young, D.C.,Kuhn, R.J.,Smith, J.L.,Pevear, D.C.,Rossmann, M.G. (deposition date: 2004-01-15, release date: 2004-04-06, Last modification date: 2011-07-13)

• Primary citation: Choi, K.H.,Groarke, J.M.,Young, D.C.,Kuhn, R.J.,Smith, J.L.,Pevear, D.C.,Rossmann, M.G.; The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.; Proc.Natl.Acad.Sci.Usa, 101:4425-4430, 2004; PubMed: 15070734; DOI: 10.1073/pnas.0400660101

Experimental method

X-RAY DIFFRACTION (3 Å)