1S3U

Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

1S3U の概要

• エントリーDOI: 10.2210/pdb1s3u/pdb
• 分子名称: Dihydrofolate reductase, SULFATE ION, (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase, inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion : P00374
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21917.12

構造登録者

Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (登録日: 2004-01-14, 公開日: 2004-03-30, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F.; Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.; Acta Crystallogr.,Sect.D, 60:646-655, 2004; PubMed: 15039552; DOI: 10.1107/S0907444904002094

実験手法

X-RAY DIFFRACTION (2.5 Å)