1S1S

Crystal Structure of ZipA in complex with indoloquinolizin 10b

Summary for 1S1S

• Entry DOI: 10.2210/pdb1s1s/pdb
• Related: 1S1J
• Descriptor: Cell division protein zipA, N-{3-[(12bS)-7-oxo-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-12(2H)-yl]propyl}propane-2-sulfonamide (3 entities in total)
• Functional Keywords: cell cycle
• Biological source: Escherichia coli
• Cellular location: Cell inner membrane; Single-pass type I membrane protein: P77173
• Total number of polymer chains: 2
• Total formula weight: 32672.51

Authors

Jennings, L.D.,Foreman, K.W.,Rush III, T.S.,Tsao, D.H.,Mosyak, L.,Li, Y.,Sukhdeo, M.N.,Ding, W.,Dushin, E.G.,Kenny, C.H.,Moghazeh, S.L.,Petersen, P.J.,Ruzin, A.V.,Tuckman, M.,Sutherland, A.G. (deposition date: 2004-01-07, release date: 2005-01-18, Last modification date: 2024-02-14)

• Primary citation: JENNINGS, L.D.,FOREMAN, K.W.,RUSH III, T.S.,TSAO, D.H.,MOSYAK, L.,LI, Y.,SUKHDEO, M.N.,DING, W.,DUSHIN, E.G.,KENNY, C.H.,MOGHAZEH, S.L.,PETERSEN, P.J.,RUZIN, A.V.,TUCKMAN, M.,SUTHERLAND, A.G.; Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction; BIOORG.MED.CHEM.LETT., 14:1427-1431, 2004; PubMed: 15006376; DOI: 10.1016/j.bmcl.2004.01.028

Experimental method

X-RAY DIFFRACTION (2.1 Å)