1S19
Crystal structure of VDR ligand binding domain complexed to calcipotriol.
Summary for 1S19
Entry DOI | 10.2210/pdb1s19/pdb |
Related | 1DB1 1IE8 1IE9 1S0Z |
Descriptor | Vitamin D3 receptor, CALCIPOTRIOL (3 entities in total) |
Functional Keywords | nuclear receptor, transcription regulation, alpha-helical sandwich, gene regulation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P11473 |
Total number of polymer chains | 1 |
Total formula weight | 30217.95 |
Authors | Tocchini-Valentini, G.,Rochel, N.,Wurtz, J.M.,Moras, D. (deposition date: 2004-01-06, release date: 2004-04-13, Last modification date: 2024-02-14) |
Primary citation | Tocchini-Valentini, G.,Rochel, N.,Wurtz, J.M.,Moras, D. Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification. J.Med.Chem., 47:1956-1961, 2004 Cited by PubMed: 15055995DOI: 10.1021/jm0310582 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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