1RW8

Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor

Summary for 1RW8

Entry DOI	10.2210/pdb1rw8/pdb
Descriptor	TGF-beta receptor type I, 3-(4-FLUOROPHENYL)-2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE (3 entities in total)
Functional Keywords	tgf-beta receptor i, protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P36897
Total number of polymer chains	1
Total formula weight	34744.90
Authors	Zhang, F.,Sawyer, J.S. (deposition date: 2003-12-16, release date: 2005-02-01, Last modification date: 2023-08-23)
Primary citation	Sawyer, J.S.,Beight, D.W.,Britt, K.S.,Anderson, B.D.,Campbell, R.M.,Goodson Jr., T.,Herron, D.K.,Li, H.Y.,McMillen, W.T.,Mort, N.,Parsons, S.,Smith, E.C.,Wagner, J.R.,Yan, L.,Zhang, F.,Yingling, J.M. Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg.Med.Chem.Lett., 14:3581-3584, 2004 Cited by PubMed: 15177479 DOI: 10.1016/j.bmcl.2004.04.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation