1RVZ

1934 H1 Hemagglutinin in complex with LSTC

1RVZ の概要

• エントリーDOI: 10.2210/pdb1rvz/pdb
• 関連するPDBエントリー: 1RU7 1RUY 1RUZ 1RV0 1RVT 1RVX
• 関連するBIRD辞書のPRD_ID: PRD_900046
• 分子名称: hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: hemagglutinin, influenza a virus, viral protein
• 由来する生物種: Influenza A virus (A/Puerto Rico/8/34(H1N1)); 詳細
• 細胞内の位置: Host apical cell membrane ; Single-pass type I membrane protein . Virion membrane ; Single-pass type I membrane protein : Q82766 Q82766
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 334564.99

構造登録者

Gamblin, S.J.,Haire, L.F.,Russell, R.J.,Stevens, D.J.,Xiao, B.,Ha, Y.,Vasisht, N.,Steinhauer, D.A.,Daniels, R.S.,Elliot, A.,Wiley, D.C.,Skehel, J.J. (登録日: 2003-12-15, 公開日: 2004-03-30, 最終更新日: 2024-10-30)

主引用文献

Gamblin, S.J.,Haire, L.F.,Russell, R.J.,Stevens, D.J.,Xiao, B.,Ha, Y.,Vasisht, N.,Steinhauer, D.A.,Daniels, R.S.,Elliot, A.,Wiley, D.C.,Skehel, J.J.
The structure and receptor binding properties of the 1918 influenza hemagglutinin.
Science, 303:1838-1842, 2004

PubMed Abstract: The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

PubMed: 14764886
DOI: 10.1126/science.1093155

実験手法

X-RAY DIFFRACTION (2.25 Å)