1RTM

TRIMERIC STRUCTURE OF A C-TYPE MANNOSE-BINDING PROTEIN

Summary for 1RTM

• Entry DOI: 10.2210/pdb1rtm/pdb
• Descriptor: MANNOSE-BINDING PROTEIN-A, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: lectin
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Secreted: P19999
• Total number of polymer chains: 3
• Total formula weight: 51284.49

Authors

Weis, W.I.,Drickamer, K. (deposition date: 1994-11-21, release date: 1995-02-07, Last modification date: 2024-10-30)

Primary citation

Weis, W.I.,Drickamer, K.
Trimeric structure of a C-type mannose-binding protein.
Structure, 2:1227-1240, 1994

PubMed Abstract: Mannose-binding proteins (MBPs) are C-type (Ca(2+)-dependent) animal lectins found in serum. They recognize cell-surface oligosaccharide structures characteristic of pathogenic bacteria and fungi, and trigger the neutralization of these organisms. Like most lectins, MBPs display weak intrinsic affinity for monovalent sugar ligands, but bind avidly to multivalent ligands.

PubMed: 7704532
DOI: 10.1016/S0969-2126(94)00124-3

Experimental method

X-RAY DIFFRACTION (1.8 Å)