1RT2

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651

1RT2 の概要

• エントリーDOI: 10.2210/pdb1rt2/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL, ... (4 entities in total)
• 機能のキーワード: nucleotidyltransferase, hiv-1 reverse transcriptase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116358.43

構造登録者

Ren, J.,Esnouf, R.,Hopkins, A.,Willcox, B.,Jones, Y.,Ross, C.,Stammers, D.,Stuart, D. (登録日: 1996-03-16, 公開日: 1997-04-21, 最終更新日: 2023-08-09)

• 主引用文献: Hopkins, A.L.,Ren, J.,Esnouf, R.M.,Willcox, B.E.,Jones, E.Y.,Ross, C.,Miyasaka, T.,Walker, R.T.,Tanaka, H.,Stammers, D.K.,Stuart, D.I.; Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.; J.Med.Chem., 39:1589-1600, 1996; PubMed: 8648598; DOI: 10.1021/jm960056x

実験手法

X-RAY DIFFRACTION (2.55 Å)