1RSI

DHNA complex with 2-Amino-5-bromo-3-hydroxy-6-phenylpyrimidine

1RSI の概要

関連するPDBエントリー1RR5 1RRI 1RRW 1RRY 1RS2 1RS4 1RSD
分子名称Dihydroneopterin aldolase, 2-AMINO-5-BROMO-6-PHENYLPYRIMIDIN-4-OL (2 entities in total)
機能のキーワード7, dhna, 8-dihydroneopterin aldolase, 2-amino-5-bromo-3-hydroxy-6-phenylpyrimidine, lyase
由来する生物種Staphylococcus aureus
ポリマー鎖数1
分子量合計14035.73
構造登録者
主引用文献
Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A.
Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47:1709-1718, 2004
PubMed: 15027862 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm030497y
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers90.8%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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