1RL6

RIBOSOMAL PROTEIN L6

1RL6 の概要

• エントリーDOI: 10.2210/pdb1rl6/pdb
• 分子名称: PROTEIN (RIBOSOMAL PROTEIN L6) (2 entities in total)
• 機能のキーワード: rna-binding protein, gentamicin resistance, ribosomal protein, alpha/beta protein, rna binding protein
• 由来する生物種: Geobacillus stearothermophilus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19202.12

構造登録者

Golden, B.L.,Davies, C.,Ramakrishnan, V.,White, S.W. (登録日: 1999-01-14, 公開日: 1999-02-02, 最終更新日: 2023-12-27)

主引用文献

Golden, B.L.,Ramakrishnan, V.,White, S.W.
Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein.
EMBO J., 12:4901-4908, 1993

PubMed Abstract: In all cells, protein synthesis is coordinated by the ribosome, a large ribonucleoprotein particle that is composed of > 50 distinct protein molecules and several large RNA molecules. Here we present the crystal structure of ribosomal protein L6 from the thermophilic bacterium Bacillus stearothermophilus solved at 2.6 A resolution. L6 contains two domains with almost identical folds, implying that it was created by an ancient gene duplication event. The surface of the molecule displays several likely sites of interaction with other components of the ribosome. The RNA binding sites appear to be localized in the C-terminal domain whereas the N-terminal domain contains the potential sites for protein-protein interactions. The domain structure is homologous with several other ribosomal proteins and to a large family of eukaryotic RNA binding proteins.

PubMed: 8262035

実験手法

X-RAY DIFFRACTION (2 Å)