1RHO

STRUCTURE OF RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR

1RHO の概要

• エントリーDOI: 10.2210/pdb1rho/pdb
• 分子名称: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION (3 entities in total)
• 機能のキーワード: gtpase activation, phosphorylation, inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50719.86

構造登録者

Keep, N.H.,Moody, P.C.E.,Roberts, G.C.K. (登録日: 1996-10-12, 公開日: 1997-10-15, 最終更新日: 2024-11-13)

主引用文献

Keep, N.H.,Barnes, M.,Barsukov, I.,Badii, R.,Lian, L.Y.,Segal, A.W.,Moody, P.C.,Roberts, G.C.
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.
Structure, 5:623-633, 1997

PubMed Abstract: The rho family of small G proteins, including rho, rac and cdc42, are involved in many cellular processes, including cell transformation by ras and the organization of the actin cytoskeleton. Additionally, rac has a role in the regulation of phagocyte NADPH oxidase. Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes.

PubMed: 9195882
DOI: 10.1016/S0969-2126(97)00218-9

実験手法

X-RAY DIFFRACTION (2.5 Å)