1REV

HIV-1 REVERSE TRANSCRIPTASE

1REV の概要

• エントリーDOI: 10.2210/pdb1rev/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE, MAGNESIUM ION, 4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE, ... (5 entities in total)
• 機能のキーワード: aids, polyprotein, hydrolase, aspartyl protease, endonuclease, nucleotidyltransferase, hiv-1 reverse transcriptase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116340.17

構造登録者

Ren, J.,Esnouf, R.,Hopkins, A.,Ross, C.,Jones, Y.,Stammers, D.,Stuart, D. (登録日: 1995-09-17, 公開日: 1996-10-14, 最終更新日: 2024-10-23)

主引用文献

Ren, J.,Esnouf, R.,Hopkins, A.,Ross, C.,Jones, Y.,Stammers, D.,Stuart, D.
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.
Structure, 3:915-926, 1995

PubMed Abstract: HIV reverse transcriptase (RT) is a key target of anti-AIDS therapies. Structural studies of HIV-1 RT, unliganded and complexed with different non-nucleoside inhibitors (NNIs), have pointed to a common mode of binding and inactivation through distortion of the polymerase catalytic site by NNIs containing two hinged rings. The mode of binding of the TIBO family of inhibitors is of interest because these compounds do not fit the two-hinged-ring model.

PubMed: 8535785
DOI: 10.1016/S0969-2126(01)00226-X

実験手法

X-RAY DIFFRACTION (2.6 Å)