1RAY
THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
Summary for 1RAY
Entry DOI | 10.2210/pdb1ray/pdb |
Descriptor | CARBONIC ANHYDRASE II, ZINC ION, AZIDE ION, ... (4 entities in total) |
Functional Keywords | lyase(oxo-acid) |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29265.29 |
Authors | Jonsson, B.M.,Hakansson, K.,Liljas, A. (deposition date: 1993-04-02, release date: 1993-10-31, Last modification date: 2024-02-14) |
Primary citation | Jonsson, B.M.,Hakansson, K.,Liljas, A. The structure of human carbonic anhydrase II in complex with bromide and azide. FEBS Lett., 322:186-190, 1993 Cited by PubMed Abstract: The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion. PubMed: 8482389DOI: 10.1016/0014-5793(93)81565-H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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