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1RAY

THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE

Summary for 1RAY
Entry DOI10.2210/pdb1ray/pdb
DescriptorCARBONIC ANHYDRASE II, ZINC ION, AZIDE ION, ... (4 entities in total)
Functional Keywordslyase(oxo-acid)
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29265.29
Authors
Jonsson, B.M.,Hakansson, K.,Liljas, A. (deposition date: 1993-04-02, release date: 1993-10-31, Last modification date: 2024-02-14)
Primary citationJonsson, B.M.,Hakansson, K.,Liljas, A.
The structure of human carbonic anhydrase II in complex with bromide and azide.
FEBS Lett., 322:186-190, 1993
Cited by
PubMed Abstract: The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion.
PubMed: 8482389
DOI: 10.1016/0014-5793(93)81565-H
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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