1RA2
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Summary for 1RA2
Entry DOI | 10.2210/pdb1ra2/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19205.13 |
Authors | Sawaya, M.R.,Kraut, J. (deposition date: 1996-10-28, release date: 1996-12-23, Last modification date: 2023-08-09) |
Primary citation | Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674DOI: 10.1021/bi962337c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report