1R7C

NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure, Sample in 50% tfe)

1R7C の概要

• エントリーDOI: 10.2210/pdb1r7c/pdb
• 関連するPDBエントリー: 1R7D 1R7E 1R7F 1R7G
• NMR情報: BMRB: 5978
• 分子名称: Genome polyprotein (1 entity in total)
• 機能のキーワード: membrane anchor domain, hcv ns5a protein, membrane protein
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3770.42

構造登録者

Penin, F.,Brass, V.,Appel, N.,Ramboarina, S.,Montserret, R.,Ficheux, D.,Blum, H.E.,Bartenschlager, R.,Moradpour, D. (登録日: 2003-10-21, 公開日: 2004-08-10, 最終更新日: 2022-03-02)

• 主引用文献: Penin, F.,Brass, V.,Appel, N.,Ramboarina, S.,Montserret, R.,Ficheux, D.,Blum, H.E.,Bartenschlager, R.,Moradpour, D.; Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.; J.Biol.Chem., 279:40835-40843, 2004; PubMed: 15247283; DOI: 10.1074/jbc.M404761200

実験手法

SOLUTION NMR