1R55

Crystal structure of the catalytic domain of human ADAM 33

1R55 の概要

• エントリーDOI: 10.2210/pdb1r55/pdb
• 関連するPDBエントリー: 1R54
• 分子名称: ADAM 33, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total)
• 機能のキーワード: metalloprotease, inhibitor, asthma, adam, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q9BZ11
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24986.22

構造登録者

Orth, P.,Reichert, P.,Wang, W.,Prosise, W.W.,Yarosh-Tomaine, T.,Hammond, G.,Xiao, L.,Mirza, U.A.,Zou, J.,Strickland, C.,Taremi, S.S.,Le, H.V.,Madison, V. (登録日: 2003-10-09, 公開日: 2004-10-12, 最終更新日: 2024-11-20)

主引用文献

Orth, P.,Reichert, P.,Wang, W.,Prosise, W.W.,Yarosh-Tomaine, T.,Hammond, G.,Xiao, L.,Mirza, U.A.,Zou, J.,Strickland, C.,Taremi, S.S.,Le, H.V.,Madison, V.
Crystal structre of the catalytic domain of human ADAM33
J.Mol.Biol., 335:129-137, 2004

PubMed Abstract: Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.

PubMed: 14659745
DOI: 10.1016/j.jmb.2003.10.037

実験手法

X-RAY DIFFRACTION (1.58 Å)