1R3M

Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease

1R3M の概要

• エントリーDOI: 10.2210/pdb1r3m/pdb
• 関連するPDBエントリー: 1BSR 1R5C 1R5D
• 分子名称: Ribonuclease, seminal, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: ribonuclease, swapping, hinge, hydrolase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P00669
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27455.22

構造登録者

Berisio, R.,Sica, F.,De Lorenzo, C.,Di Fiore, A.,Piccoli, R.,Zagari, A.,Mazzarella, L. (登録日: 2003-10-02, 公開日: 2003-11-18, 最終更新日: 2024-11-13)

主引用文献

Berisio, R.,Sica, F.,De Lorenzo, C.,Di Fiore, A.,Piccoli, R.,Zagari, A.,Mazzarella, L.
Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease
Febs Lett., 554:105-110, 2003

PubMed Abstract: Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state.

PubMed: 14596923
DOI: 10.1016/S0014-5793(03)01114-1

実験手法

X-RAY DIFFRACTION (2.2 Å)