Summary for 1Z7K
| Entry DOI | 10.2210/pdb1z7k/pdb |
| Descriptor | Trypsin, Ovomucoid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | serine protease, hydrolase, protease inhibitor, di-nag, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Sus scrofa (pig) More |
| Cellular location | Secreted, extracellular space: P00761 Secreted: P68390 P68390 |
| Total number of polymer chains | 3 |
| Total formula weight | 31092.86 |
| Authors | Syed Ibrahim, B.,Pattabhi, V. (deposition date: 2005-03-25, release date: 2005-04-05, Last modification date: 2024-11-13) |
| Primary citation | Syed Ibrahim, B.,Pattabhi, V. Crystal structure of trypsin-turkey egg white inhibitor complex Biochem.Biophys.Res.Commun., 313:8-16, 2004 Cited by PubMed Abstract: Crystal structure of the complex between porcine beta-trypsin and the second domain of the Kazal-type ovomucoid turkey egg white trypsin inhibitor (OMTKY2) has been determined at 1.9A resolution. A peptide fragment from the first domain has been crystallized with the complex. Restrained-refinement of the structure led to an R-factor of 0.19 for the 32206 reflections. OMTKY2 exhibits the canonical Kazal-type fold with a central alpha-helix and a short two-stranded anti-parallel beta-sheet. The carbonyl carbon of the reactive site prefers trigonal geometry. The reactive site loop geometry of the inhibitor is complementary to the surface and charge of the binding site in beta-trypsin. PubMed: 14672690DOI: 10.1016/j.bbrc.2003.11.082 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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