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1R0P

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a

Summary for 1R0P
Entry DOI10.2210/pdb1r0p/pdb
DescriptorHepatocyte growth factor receptor, K-252A (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, signal transduction, grb2, shc, transferase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains1
Total formula weight35774.37
Authors
Schiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C. (deposition date: 2003-09-22, release date: 2003-10-07, Last modification date: 2024-02-14)
Primary citationSchiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C.
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Proc.Natl.Acad.Sci.USA, 100:12654-12659, 2003
Cited by
PubMed: 14559966
DOI: 10.1073/pnas.1734128100
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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