1R0P
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Summary for 1R0P
Entry DOI | 10.2210/pdb1r0p/pdb |
Descriptor | Hepatocyte growth factor receptor, K-252A (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, signal transduction, grb2, shc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35774.37 |
Authors | Schiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C. (deposition date: 2003-09-22, release date: 2003-10-07, Last modification date: 2024-02-14) |
Primary citation | Schiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Proc.Natl.Acad.Sci.USA, 100:12654-12659, 2003 Cited by PubMed: 14559966DOI: 10.1073/pnas.1734128100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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