1R0P

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a

1R0P の概要

• エントリーDOI: 10.2210/pdb1r0p/pdb
• 分子名称: Hepatocyte growth factor receptor, K-252A (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, signal transduction, grb2, shc, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35774.37

構造登録者

Schiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C. (登録日: 2003-09-22, 公開日: 2003-10-07, 最終更新日: 2024-02-14)

• 主引用文献: Schiering, N.,Knapp, S.,Marconi, M.,Flocco, M.M.,Cui, J.,Perego, R.,Rusconi, L.,Cristiani, C.; Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a; Proc.Natl.Acad.Sci.USA, 100:12654-12659, 2003; PubMed: 14559966; DOI: 10.1073/pnas.1734128100

実験手法

X-RAY DIFFRACTION (1.8 Å)