1QXO
Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP
Summary for 1QXO
| Entry DOI | 10.2210/pdb1qxo/pdb |
| Descriptor | Chorismate synthase, COBALT HEXAMMINE(III), 1,2-ETHANEDIOL, ... (6 entities in total) |
| Functional Keywords | beta-alpha-beta, flavoprotein, shikimate, anti-infective, lyase |
| Biological source | Streptococcus pneumoniae |
| Total number of polymer chains | 4 |
| Total formula weight | 179897.00 |
| Authors | Maclean, J.,Ali, S. (deposition date: 2003-09-08, release date: 2003-12-23, Last modification date: 2024-10-30) |
| Primary citation | Maclean, J.,Ali, S. The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction Structure, 11:1499-1511, 2003 Cited by PubMed Abstract: The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 A resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential therapeutic target for the rational design of novel antibacterials, antifungals, antiprotozoals, and herbicides. CS is a tetramer with the monomer possessing a novel beta-alpha-beta fold. The interactions between the enzyme, cofactor, and substrate reveal the structural reasons underlying the unique catalytic mechanism and identify the amino acids involved. This structure provides the essential initial information necessary for the generation of novel anti-infective compounds by a structure-guided medicinal chemistry approach. PubMed: 14656434DOI: 10.1016/j.str.2003.11.005 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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