1QXE

Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

1QXE の概要

• エントリーDOI: 10.2210/pdb1qxe/pdb
• 関連するPDBエントリー: 1QXD
• 分子名称: Hemoglobin alpha chain, Hemoglobin beta chain, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: allosteric; antisickling; relaxed state; hemoglobin; sickle cell; 5-hydroxymethyl-2-furfural, oxygen storage-transport complex, oxygen storage/transport
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65599.71

構造登録者

Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J. (登録日: 2003-09-05, 公開日: 2003-09-16, 最終更新日: 2023-08-23)

• 主引用文献: Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Burnett, J.C.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J.; Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds; J.Med.Chem., 47:4665-4676, 2004; PubMed: 15341482; DOI: 10.1021/jm0498001

実験手法

X-RAY DIFFRACTION (1.85 Å)