1QR1

POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE

1QR1 の概要

• エントリーDOI: 10.2210/pdb1qr1/pdb
• 関連するPDBエントリー: 1hhg 1hhh 1hhi 1hhj 1hhk
• 分子名称: HLA-A2.1 HEAVY CHAIN, BETA-2 MICROGLOBULIN, GP2 PEPTIDE, ... (4 entities in total)
• 機能のキーワード: peptide-binding superdomain, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89235.35

構造登録者

Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J. (登録日: 1999-06-17, 公開日: 2000-01-01, 最終更新日: 2021-11-03)

• 主引用文献: Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J.; Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.; J.Biol.Chem., 274:36422-36427, 1999; PubMed: 10593938; DOI: 10.1074/jbc.274.51.36422

実験手法

X-RAY DIFFRACTION (2.4 Å)