1QQH

2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN

1QQH の概要

• エントリーDOI: 10.2210/pdb1qqh/pdb
• 分子名称: PAPILLOMAVIRUS TRANSCRIPTION FACTOR E2 (2 entities in total)
• 機能のキーワード: amphipathic helix, cashew/kidney shape, viral protein
• 由来する生物種: Human papillomavirus type 18
• 細胞内の位置: Host nucleus : P06790
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16481.14

構造登録者

Harris, S.F.,Botchan, M.R. (登録日: 1999-06-05, 公開日: 1999-06-21, 最終更新日: 2024-02-14)

主引用文献

Harris, S.F.,Botchan, M.R.
Crystal structure of the human papillomavirus type 18 E2 activation domain.
Science, 284:1673-1677, 1999

PubMed Abstract: The papillomavirus E2 protein regulates viral transcription and DNA replication through interactions with cellular and viral proteins. The amino-terminal activation domain, which represents a protein class whose structural themes are poorly understood, contains key residues that mediate these functional contacts. The crystal structure of a protease-resistant core of the human papillomavirus type 18 E2 activation domain reveals a novel fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet framework. The protein surface shows extensive overlap of determinants for replication and transcription. The structure broadens the concept of activators to include proteins with potentially malleable, but certainly ordered, structures.

PubMed: 10356398
DOI: 10.1126/science.284.5420.1673

実験手法

X-RAY DIFFRACTION (2.1 Å)