1QPQ

Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target

1QPQ の概要

• エントリーDOI: 10.2210/pdb1qpq/pdb
• 分子名称: QUINOLINATE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION, QUINOLINIC ACID, ... (4 entities in total)
• 機能のキーワード: type ii prtase, de novo nad biosynthesis, prpp, phosphoribosyl transferase, quinolinic acid, structural genomics, psi, protein structure initiative, tb structural genomics consortium, tbsgc, transferase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 180684.27

構造登録者

Sharma, V.,Grubmeyer, C.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 1998-11-20, 公開日: 1998-11-25, 最終更新日: 2023-12-27)

主引用文献

Sharma, V.,Grubmeyer, C.,Sacchettini, J.C.
Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6:1587-1599, 1998

PubMed Abstract: . Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid, a frontline antimycobacterial drug, suggests that NAD metabolism is extremely critical for this microorganism. M. tuberculosis depends solely on the de novo pathway to meet its NAD demand. Quinolinic acid phosphoribosyltransferase (QAPRTase), a key enzyme in the de novo biosynthesis of NAD, provides an attractive target for designing novel antitubercular drugs.

PubMed: 9862811
DOI: 10.1016/S0969-2126(98)00156-7

実験手法

X-RAY DIFFRACTION (2.45 Å)