1QHL

CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF MUKB AT 2.2A RESOLUTION

1QHL の概要

• エントリーDOI: 10.2210/pdb1qhl/pdb
• 分子名称: PROTEIN (CELL DIVISION PROTEIN MUKB) (2 entities in total)
• 機能のキーワード: mukb, smc, chromosome partitioning, cell division protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm, nucleoid: P22523
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25246.98

構造登録者

van den Ent, F.,Lowe, J. (登録日: 1999-05-17, 公開日: 1999-11-10, 最終更新日: 2023-12-27)

主引用文献

van den Ent, F.,Lockhart, A.,Kendrick-Jones, J.,Lowe, J.
Crystal structure of the N-terminal domain of MukB: a protein involved in chromosome partitioning.
Structure Fold.Des., 7:1181-1187, 1999

PubMed Abstract: The 170 kDa protein MukB has been implicated in ATP-dependent chromosome partitioning during cell division in Escherichia coli. MukB shares its dimeric structure and domain architecture with the ubiquitous family of SMC (structural maintenance of chromosomes) proteins that facilitate similar functions. The N-terminal domain of MukB carries a putative Walker A nucleotide-binding region and the C-terminal domain has been shown to bind to DNA. Mutant phenotypes and a domain arrangement similar to motor proteins that move on microtubules led to the suggestion that MukB might be a motor protein acting on DNA.

PubMed: 10545328
DOI: 10.1016/S0969-2126(00)80052-0

実験手法

X-RAY DIFFRACTION (2.2 Å)