1QFF

E. COLI FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) IN COMPLEX WITH BOUND FERRICHROME-IRON

1QFF の概要

• エントリーDOI: 10.2210/pdb1qff/pdb
• 関連するPDBエントリー: 1QFG
• 分子名称: FERRIC HYDROXAMATE UPTAKE RECEPTOR, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2,3-dideoxy-alpha-D-glucoyranose-(1-6)-2-amino-2-deoxy-alpha-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: tonb-dependent receptor, integral outer membrane protein, siderophore-iron receptor, active transport, lipopolysaccharide, ferrichrome receptor, metal transport
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 85237.85

構造登録者

Ferguson, A.D.,Hofmann, E.,Coulton, J.W.,Diederichs, K.,Welte, W. (登録日: 1999-04-10, 公開日: 2000-07-26, 最終更新日: 2024-10-30)

主引用文献

Ferguson, A.D.,Welte, W.,Hofmann, E.,Lindner, B.,Holst, O.,Coulton, J.W.,Diederichs, K.
A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins.
Structure Fold.Des., 8:585-592, 2000

PubMed Abstract: Lipopolysaccharide (LPS), a lipoglycan from the outer membrane of Gram-negative bacteria, is an immunomodulatory molecule that stimulates the innate immune response. High levels of LPS cause excessive release of inflammatory mediators and are responsible for the septic shock syndrome. The interaction of LPS with its cognate binding proteins has not, as yet, been structurally elucidated.

PubMed: 10873859
DOI: 10.1016/S0969-2126(00)00143-X

実験手法

X-RAY DIFFRACTION (2.7 Å)