1QDN
AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)
Summary for 1QDN
| Entry DOI | 10.2210/pdb1qdn/pdb |
| Descriptor | PROTEIN (N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)), SULFATE ION, BETA-MERCAPTOETHANOL, ... (4 entities in total) |
| Functional Keywords | double-psi beta barrel alpha/beta barrel, vesicular-fusion protein, fusion protein |
| Biological source | Cricetulus griseus (Chinese hamster) |
| Cellular location | Cytoplasm: P18708 |
| Total number of polymer chains | 3 |
| Total formula weight | 68754.18 |
| Authors | May, A.P.,Misura, K.M.S.,Whiteheart, S.W.,Weis, W.I. (deposition date: 1999-05-21, release date: 1999-06-21, Last modification date: 2025-03-26) |
| Primary citation | May, A.P.,Misura, K.M.,Whiteheart, S.W.,Weis, W.I. Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein. Nat.Cell Biol., 1:175-182, 1999 Cited by PubMed Abstract: The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure. PubMed: 10559905DOI: 10.1038/11097 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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