1QD1

THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.

1QD1 の概要

• エントリーDOI: 10.2210/pdb1qd1/pdb
• 分子名称: FORMIMINOTRANSFERASE-CYCLODEAMINASE, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: functional dimer, alpha-beta-beta-alpha sandwich, electrostatically charged substrate tunnel, transferase
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome, centriole (By similarity): P53603
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72888.89

構造登録者

Kohls, D.,Sulea, T.,Purisima, E.,MacKenzie, R.E.,Vrielink, A. (登録日: 1999-07-08, 公開日: 2000-01-12, 最終更新日: 2024-02-14)

主引用文献

Kohls, D.,Sulea, T.,Purisima, E.O.,MacKenzie, R.E.,Vrielink, A.
The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.
Structure Fold.Des., 8:35-46, 2000

PubMed Abstract: The bifunctional enzyme formiminotransferase-cyclodeaminase (FTCD) contains two active sites at different positions on the protein structure. The enzyme binds a gamma-linked polyglutamylated form of the tetrahydrofolate substrate and channels the product of the transferase reaction from the transferase active site to the cyclodeaminase active site. Structural studies of this bifunctional enzyme and its monofunctional domains will provide insight into the mechanism of substrate channeling and the two catalytic reactions.

PubMed: 10673422
DOI: 10.1016/S0969-2126(00)00078-2

実験手法

X-RAY DIFFRACTION (1.7 Å)