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1QBT

HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY

Summary for 1QBT
Entry DOI10.2210/pdb1qbt/pdb
DescriptorHIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE] (2 entities in total)
Functional Keywordshydrolase (acid proteinase), aspartyl protease
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains2
Total formula weight22340.25
Authors
Ala, P.,Chang, C.-H. (deposition date: 1997-04-25, release date: 1997-10-15, Last modification date: 2024-02-14)
Primary citationJadhav, P.K.,Ala, P.,Woerner, F.J.,Chang, C.H.,Garber, S.S.,Anton, E.D.,Bacheler, L.T.
Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40:181-191, 1997
Cited by
PubMed: 9003516
DOI: 10.1021/jm960586t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

218853

数据于2024-04-24公开中

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