1QBH

SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT

1QBH の概要

• エントリーDOI: 10.2210/pdb1qbh/pdb
• 分子名称: INHIBITOR OF APOPTOSIS PROTEIN (2MIHB/C-IAP-1), ZINC ION (2 entities in total)
• 機能のキーワード: inhibitor of apoptosis (iap), baculoviral iap repeat (bir), zinc binding domain, apoptosis
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (Potential): Q13490
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11842.73

構造登録者

Hinds, M.G.,Norton, R.S.,Vaux, D.L.,Day, C.L. (登録日: 1999-04-20, 公開日: 1999-10-20, 最終更新日: 2024-05-22)

主引用文献

Hinds, M.G.,Norton, R.S.,Vaux, D.L.,Day, C.L.
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.
Nat.Struct.Biol., 6:648-651, 1999

PubMed Abstract: Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.

PubMed: 10404221
DOI: 10.1038/10701

実験手法

SOLUTION NMR