1Q6K

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

1Q6K の概要

• エントリーDOI: 10.2210/pdb1q6k/pdb
• 分子名称: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE, ... (4 entities in total)
• 機能のキーワード: cathepsin k, catk, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23860.87

構造登録者

Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. (登録日: 2003-08-13, 公開日: 2004-03-16, 最終更新日: 2024-10-30)

主引用文献

Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L.
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
Bioorg.Med.Chem.Lett., 14:275-278, 2004

PubMed Abstract: The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.

PubMed: 14684342
DOI: 10.1016/j.bmcl.2003.09.088

実験手法

X-RAY DIFFRACTION (2.1 Å)