1Q5C
S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Summary for 1Q5C
| Entry DOI | 10.2210/pdb1q5c/pdb |
| Related | 1L3W 1Q55 1Q5A 1Q5B |
| EMDB information | 1052 |
| Descriptor | EP-cadherin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (4 entities in total) |
| Functional Keywords | cadherin; trans interaction; desmosome; junction; adhesion, structural protein |
| Biological source | Mus musculus (house mouse) |
| Total number of polymer chains | 4 |
| Total formula weight | 406209.63 |
| Authors | He, W.,Cowin, P.,Stokes, D.L. (deposition date: 2003-08-06, release date: 2003-10-07, Last modification date: 2020-07-29) |
| Primary citation | He, W.,Cowin, P.,Stokes, D.L. Untangling Desmosomal Knots with Electron Tomography Science, 302:109-113, 2003 Cited by PubMed Abstract: Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction. PubMed: 14526082DOI: 10.1126/science.1086957 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (30 Å) |
Structure validation
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