1Q4X

Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24

Summary for 1Q4X

Entry DOI	10.2210/pdb1q4x/pdb
Descriptor	Thyroid hormone receptor beta-1, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID (3 entities in total)
Functional Keywords	conformational change in two framework helices upon ligand binding, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10828
Total number of polymer chains	1
Total formula weight	29334.97
Authors	Borngraeber, S.,Budny, M.J.,Chiellini, G.,Cunha-Lima, S.T.,Togashi, M.,Webb, P.,Baxter, J.D.,Scanlan, T.S.,Fletterick, R.J. (deposition date: 2003-08-04, release date: 2004-02-03, Last modification date: 2024-04-03)
Primary citation	Borngraeber, S.,Budny, M.J.,Chiellini, G.,Cunha-Lima, S.T.,Togashi, M.,Webb, P.,Baxter, J.D.,Scanlan, T.S.,Fletterick, R.J. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc.Natl.Acad.Sci.USA, 100:15358-15363, 2003 Cited by PubMed: 14673100 DOI: 10.1073/pnas.2136689100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation