1Q13

Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone

1Q13 の概要

• エントリーDOI: 10.2210/pdb1q13/pdb
• 分子名称: Prostaglandin-E2 9-reductase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: 20alpha-hsd, hydroxysteroid dehydrogenase, aldo-keto reductase, tim-barrel, akr, testosterone, ternary complex, oxidoreductase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Cytoplasm: P80508
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75311.76

構造登録者

Couture, J.-F.,Cantin, L.,Legrand, P.,Luu-The, V.,Labrie, F.,Breton, R. (登録日: 2003-07-18, 公開日: 2004-11-16, 最終更新日: 2024-02-14)

• 主引用文献: Couture, J.F.,Legrand, P.,Cantin, L.,Labrie, F.,Luu-The, V.,Breton, R.; Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.; J. Mol. Biol., 339:89-102, 2004; PubMed: 15123423; DOI: 10.1016/j.jmb.2004.03.035

実験手法

X-RAY DIFFRACTION (2.08 Å)