1PYN の概要
| 関連するPDBエントリー | 1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO |
|---|---|
| 分子名称 | Protein-tyrosine phosphatase, non-receptor type 1, 2-(4-{2-TERT-BUTOXYCARBONYLAMINO-2-[4-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-BUTYLCARBAMOYL]-ETHYL}-PHENOXY)-MALONIC ACID (3 entities in total) |
| 機能のキーワード | protein tyrosine phosphatase inhibited with dual site, malonate-containing inhibitor, hydrolase |
| 由来する生物種 | Homo sapiens (human) |
| 細胞内の位置 | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side P18031 |
| ポリマー鎖数 | 1 |
| 分子量合計 | 37970.24 |
| 構造登録者 | Szczepankiewicz, B.G.,Liu, G.,Hajduk, P.J.,Abad-Zapatero, C.,Zhonghua, P.,Lubben, T.,Trevillyan, J.M.,Stashko, M.,Ballaron, S.J.,Liang, H. (登録日: 2003-07-09, 公開日: 2003-09-16, 最終更新日: 2017-10-11) |
| 主引用文献 | Pei, Z.,Li, X.,Liu, G.,Abad-Zapatero, C.,Lubben, T.,Zhang, T.,Ballaron, S.J.,Hutchins, C.W.,Trevillyan, J.M.,Jirousek, M.R. Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem.Lett., 13:3129-3132, 2003 PubMed: 12951078 (主引用文献が同じPDBエントリー) DOI: 10.1016/S0960-894X(03)00725-X  Import into Mendeley |
| 実験手法 | X-RAY DIFFRACTION (2.2 Å) |
| NMR情報 |
