Crystal structure of CDK2 with inhibitor

Summary for 1PYE

DescriptorCell division protein kinase 2, [2-AMINO-6-(2,6-DIFLUORO-BENZOYL)-IMIDAZO[1,2-A]PYRIDIN-3-YL]-PHENYL-METHANONE (3 entities in total)
Functional Keywordscdk, cyclin-dependent kinase 2, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34353.83
Zhang, F.,Hamdouchi, C. (deposition date: 2003-07-08, release date: 2004-07-13, Last modification date: 2011-07-13)
Primary citation
Hamdouchi, C.,Keyser, H.,Collins, E.,Jaramillo, C.,De Diego, J.E.,Spencer, C.D.,Dempsey, J.A.,Anderson, B.D.,Leggett, T.,Stamm, N.B.,Schultz, R.M.,Watkins, S.A.,Cocke, K.,Lemke, S.,Burke, T.F.,Beckmann, R.P.,Dixon, J.T.,Gurganus, T.M.,Rankl, N.B.,Houck, K.A.,Zhang, F.,Vieth, M.,Espinosa, J.,Timm, D.E.,Campbell, R.M.,Patel, B.K.,Brooks, H.B.
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
MOL.CANCER THER., 3:1-9, 2004
PubMed: 14749470 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers140.4%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report