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1PWU

Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.

Summary for 1PWU
Entry DOI10.2210/pdb1pwu/pdb
Related1PQW 1PWP 1PWV 1PWW
DescriptorLethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE (3 entities in total)
Functional Keywordsanthrax toxin, lethal factor, small molecule peptidic inhibitor, hydroxamic acid., hydrolase
Biological sourceBacillus anthracis
Cellular locationSecreted: P15917
Total number of polymer chains2
Total formula weight181569.41
Authors
Wong, T.Y.,Schwarzenbacher, R.,Liddington, R.C. (deposition date: 2003-07-02, release date: 2004-02-03, Last modification date: 2023-08-16)
Primary citationTurk, B.E.,Wong, T.Y.,Schwarzenbacher, R.,Jarrell, E.T.,Leppla, S.H.,Collier, R.J.,Liddington, R.C.,Cantley, L.C.
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11:60-66, 2004
Cited by
PubMed: 14718924
DOI: 10.1038/nsmb708
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

건을2024-03-27부터공개중

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