1PWQ

Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor

Summary for 1PWQ

• Entry DOI: 10.2210/pdb1pwq/pdb
• Related: 1PWP
• Descriptor: Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE (3 entities in total)
• Functional Keywords: anthrax toxin, lethal factor, metal-chelator, small molecule peptidic inhibitor, hydrolase
• Biological source: Bacillus anthracis
• Cellular location: Secreted: P15917
• Total number of polymer chains: 2
• Total formula weight: 181809.68

Authors

Wong, T.Y.,Schwarzenbacher, R.,Liddington, R.C. (deposition date: 2003-07-02, release date: 2004-01-13, Last modification date: 2023-08-16)

• Primary citation: Turk, B.E.,Wong, T.Y.,Schwarzenbacher, R.,Jarrell, E.T.,Leppla, S.H.,Collier, R.J.,Liddington, R.C.,Cantley, L.C.; The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.; Nat.Struct.Mol.Biol., 11:60-66, 2004; PubMed: 14718924; DOI: 10.1038/nsmb708

Experimental method

X-RAY DIFFRACTION (3.52 Å)